Demonstration Formulary
 
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4 Central nervous system

PALLIATIVE CARE PHYSICIANS - Guidelines for the use of drugs in symptom control

 

04-08-01 Valproate

Sodium Valproate
Formulary

E/C tablets

M/R tablets

Crushable tablets

SF liquid

M/R granules see Episenta®

On specialist advice

 Use in men and women of non-child bearing potential

 Use in women and girls of childbearing potential (all indications).

Contraindicated in women of childbearing potential unless part of the Pregnancy Prevention Programme. See MHRA guidance

MHRA Advice
Care should be taken when switching between oral formulations. The need for continued supply of a particular manufacturer’s product should be based on clinical judgement and consultation with patient and/or carer, taking into account factors such as seizure frequency and treatment history

Link  MHRA: Valproate Pregnancy Prevention Programme: temporary advice for management during coronavirus (COVID-19) pandemic
Link  Guidance Document on Valproate Use in Women and Girls of Childbearing Years (March 2019)
Link  Valproate form: Annual Risk Acknowledgement form (March 2019)
Link  Medicines related to valproate: risk of abnormal pregnancy outcomes
Link  MHRA : Valproate use in women and girls (August 2018)
Link  NICE CG137: Epilepsies: diagnosis and management
Link  Women of childbearing potential: Educational Risk Minimisation Materials

View adult BNF  View SPC online  View childrens BNF
Sodium valproate prolonged release Episenta®
Formulary

Paediatrician initiation for patients with epilepsy aged up to and including 16 years of age unable to swallow tablets and who require a modified release formulation in whom other formulations are more expensive or not appropriate

Contraindicated in women of childbearing potential unless part of the Pregnancy Prevention Programme. See MHRA guidance

MHRA Advice
Care should be taken when switching between oral formulations. The need for continued supply of a particular manufacturer’s product should be based on clinical judgement and consultation with patient and/or carer, taking into account factors such as seizure frequency and treatment history

Link  MHRA: Valproate Pregnancy Prevention Programme: temporary advice for management during coronavirus (COVID-19) pandemic
Link  Guidance Document on Valproate Use in Women and Girls of Childbearing Years (March 2019)
Link  Valproate form: Annual Risk Acknowledgement form (March 2019)
Link  Medicines related to valproate: risk of abnormal pregnancy outcomes
Link  MHRA: Valproate use in women and girls (August 2018)
Link  NICE CG137: Epilepsies: diagnosis and management
Link  Women of childbearing potential: Educational Risk Minimisation Materials

Specialist initiation View adult BNF  View SPC online  View childrens BNF