| Formulary Chapter 4: Central nervous system - Full Chapter
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 Administration of depot antipsychotic injections during COVID-19 in stable adult patients |
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| 04.03 |
Antidepressant drugs |
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| 04.03.01 |
Tricyclic and related antidepressant drugs |
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| 04.03.01 |
Tricyclic antidepressants |
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Amitriptyline
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Formulary
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Tablets more cost effective than SF solution
Sugar Free solution £££££
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Clomipramine
(Capsules)
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Formulary
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An alternative to SSRIs in obsessive-compulsive disorder (OCD)
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Imipramine
(tablets)
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Formulary
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Lofepramine
(Tablets and Suspension)
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Formulary
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| 04.03.01 |
Related antidepressants |
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Trazodone
(Oral)
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Formulary
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Tablets
Capsules
SF Liquid
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| 04.03.02 |
Monoamine-oxidase inhibitors |
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| 04.03.02 |
Reverible MAOIs |
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Moclobemide
(tablets)
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Formulary
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| 04.03.03 |
Selective serotonin re-uptake inhibitors |
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Fluoxetine
(capsules)
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First Choice
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Sertraline
(tablets)
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First Choice
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Citalopram
(tablets)
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Formulary
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Risk of QT prolongation
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MHRA: New maximum daily dose restrictions (including in elderly patients), contraindications, and warnings
UKMI Q&A: What issues should be considered regarding drug induced QT prolongation?
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Citalopram
(oral drops)
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Formulary
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4 drops (8 mg) is equivalent in therapeutic effect to 10mg tablet
Risk of QT prolongation
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MHRA: New maximum daily dose restrictions (including in elderly patients), contraindications, and warnings
UKMI Q&A: What issues should be considered regarding drug induced QT prolongation?
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Fluoxetine
(liquid)
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Formulary
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Paroxetine
(tablets)
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Formulary
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Vortioxetine
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Formulary
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In line with NICE
Specialist initiation and stabilisation before transfer to Primary Care
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NICE TA367: Vortioxetine for treating major depressive episodes (Nov 2015)
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| 04.03.04 |
Other antidepressant drugs |
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Pregabalin
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Second Choice
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£££££
For generalised anxiety disorder
Please follow Optimise Rx for most cost effective brand
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NHS England: (Schedule 3 Controlled Drugs) Patient Leaflet; Are you taking gabapentin or pregabalin? (Lyrica, Alzain, Neurontin)
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Agomelatine (Valdoxan®)
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Formulary
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Supported by a RICaD (in development)
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TA231: Agomelatine for the treatment of major depressive episodes (terminated appraisal)
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Duloxetine (Cymbalta®)
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Formulary
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Mirtazapine
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Formulary
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- Tablets
- Orodispersible tablets ££
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Venlafaxine
(standard release tablets)
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Formulary
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Venlafaxine
(modified release )
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Formulary
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1st choice = Vensir XL capsules (suggest switching generic prescriptions to this agent)
2nd choice = Venlalic XL tablets
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Bupropion
(off label)
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Formulary
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Hospital use only
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Tryptophan
(tablets)
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Formulary
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Hospital use only
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| Non Formulary Items |
Amitriptyline and perphenazine (Triptafen®, Triptafen-M®)
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Non Formulary
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Dosulepin
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Non Formulary
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- Tablets
- Capsules
- Sugar free solution
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 Patient Information: Changes to dosulepin prescribing
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Doxepin
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Non Formulary
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Escitalopram (Cipralex®)
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Non Formulary
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Fluvoxamine Maleate (Faverin®, Fluvoxamine®)
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Non Formulary
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Isocarboxazid
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Non Formulary
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Melatonin
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Non Formulary
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Mianserin
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Non Formulary
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Moclobemide
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Non Formulary
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Nortriptyline
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Non Formulary
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Phenelzine (Nardil®)
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Non Formulary
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Reboxetine (Edronex®)
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Non Formulary
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Tranylcypromine
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Non Formulary
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Trimipramine
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Non Formulary
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Patient Information: Changes to trimipramine prescribing
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Key |
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Restricted Drug |
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Unlicensed |
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Link to adult BNF
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Link to children's BNF
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Link to SPCs
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Cytotoxic Drug |
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Controlled Drug |
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High Cost Medicine |
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Cancer Drugs Fund |
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NHS England |
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Homecare |
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ICB |
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Low carbon footprint |
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Medium carbon footprint |
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High carbon footprint |
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| Status |
Description |
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All Settings
Suitable for initiation, ongoing prescribing, and discontinuation in both primary and secondary care settings. They are generally familiar, frequently used therapies that can be started within their licensed indications without specialist oversight. |
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Specialist only
Designated for initiation, ongoing prescribing, monitoring, exclusively by a specialists either in a hospital or as part of a specialist service (to note this could be in a non-hospital setting). Primary care should neither start nor continue these treatments except as part of a specialist service. A specialist could be either a medical or non-medical prescriber. |
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Specialist advice
Prescribers in primary care should seek advice and a recommendation from a specialists prior to initiating a medicine. Once agreed with a specialist, medicines can be initiated, prescribed and monitored in primary care without a formal shared-care agreement. |
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Specialist initiation
Medicines in this category require a specialist to start therapy, titrate dosage, and assess initial efficacy or tolerability. Once stabilised, prescribing responsibility may transfer to primary care without the need for a formal shared-care agreement. |
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Shared care agreement
Prescribing responsibility can be shared across health settings and between specialists and GPs only when formal shared care arrangement has been made. For example, there may be extensive and complex monitoring requirements or significant safety concerns (note would need a national policy on this to define the criteria for requiring a formal SCA), this will be produced once nationally. |
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Do not prescribe
Not approved for routine prescribing in primary or secondary care. For example, because they are agents classified in the BNF as “not NHS” or “Drugs of Low Clinical Value”, or they are products on NICE’s “do not do” list or NHS England’s “should not routinely prescribe” list. |
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Self Care
Not for routine prescribed in primary or secondary care unless as part of care for a long term condition. Instead, patients should be encouraged to self care with support from community pharmacy. |
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Medicines which are suitable for initiation and maintenance prescribing by primary and secondary care clinicians. These medicines should be initiated and prescribed within their licensed indications |
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Amber Specialist Initiation: Initiation and maintenance of prescribing by Specialists and transfer to Primary Care prescribing when appropriate. This may be supported by a RICaD, annotated within the formulary entry. |
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Amber Shared Care: Initiation and maintenance of prescribing by Specialists and transfer to Primary Care prescribing, in accordance with an ESCA, annotated within the formulary entry. |
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Amber Specialist Recommendation: Initiation and maintenance of prescribing in Primary Care following recommendation from a specialist. |
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Medicines for initiation and maintenance prescribing by Specialists (hospital or GPs with Special Interest) only |
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Positive NICE TA and /or awaiting local clarification on place in therapy; Please contact your Medicines Optimisation team for more information. |
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Non-formulary Medicines which APC/Trust DTC has actively reviewed and do not recommend for use. |
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